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王金勇，男，博士，研究員，博士生導(dǎo)師，中科院""百人計(jì)劃""獲得者，廣東省百千萬(wàn)工程領(lǐng)軍人才，美國(guó)血液學(xué)會(huì)會(huì)員。2006年獲浙江大學(xué)博士學(xué)位，2007年赴美國(guó)留學(xué)，先后在威斯康星醫(yī)學(xué)院（Medical College of Wisconsin）病理系、威斯康星大學(xué)（University of Wisconsin-Madison）醫(yī)學(xué)與公共衛(wèi)生學(xué)院腫瘤系從事博士后研究，2011年晉升為該校助理研究員（Assistant Scientist）。2012年三月加入中國(guó)科學(xué)院廣州生物醫(yī)藥與健康研究院，負(fù)責(zé)組建造血干細(xì)胞與再生醫(yī)學(xué)研究室。在美國(guó)留學(xué)期間，系統(tǒng)地建立了含有Ras突變的了人CMML（慢性髓系單核粒細(xì)胞白血?。ALL（急性T細(xì)胞白血?。┑男∈竽Ｐ?，并且基于上述模型發(fā)現(xiàn)了幾種藥物抑制劑；開(kāi)發(fā)出單細(xì)胞水平上分析造血干細(xì)胞磷酸化信號(hào)轉(zhuǎn)導(dǎo)的新技術(shù)，基于此技術(shù)發(fā)現(xiàn)了造血干細(xì)胞獨(dú)特的信號(hào)轉(zhuǎn)導(dǎo)現(xiàn)象；發(fā)現(xiàn)MAPK通路調(diào)控造血干細(xì)胞的干性維持、自我復(fù)制與分化支系偏好，闡明了相應(yīng)的分子機(jī)制。
他的研究團(tuán)隊(duì)長(zhǎng)期從事造血調(diào)控與再生研究，旨在結(jié)合體內(nèi)誘導(dǎo)譜系重編程、體外誘導(dǎo)干細(xì)胞分化、造血骨髓微環(huán)境原位重建等多途徑探索血細(xì)胞（包括T細(xì)胞）再生與生理功能重建。其研究團(tuán)隊(duì)在重編程再生造血干細(xì)胞、誘導(dǎo)干細(xì)胞分化再生T細(xì)胞、體內(nèi)重編程再生T細(xì)胞等研究領(lǐng)域做出一系列原創(chuàng)性貢獻(xiàn)。他的課題組得到多項(xiàng)國(guó)家自然科學(xué)基金項(xiàng)目（5項(xiàng)）、國(guó)家重大研發(fā)計(jì)劃課題（2項(xiàng)）和廣東省重大科技專項(xiàng)（2項(xiàng)）、廣州市健康醫(yī)療協(xié)同創(chuàng)新重大專項(xiàng)等的支持。研究團(tuán)隊(duì)的成果已申請(qǐng)多項(xiàng)國(guó)際PCT專利保護(hù)，部分成果在 Nature Immunology, Blood, Cell Cycle, Stem Cell Research,Am J Transl等刊物發(fā)表。
1. Mengyun Zhang# , Yong Dong#, Fangxiao Hu#, Dan Yang, Qianhao Zhao, Cui Lv, Ying Wang, Chengxiang Xia, Qitong Weng, Xiaofei Liu, Chen Li, Peiqing Zhou, Tongjie Wang, Yuxian Guan, Rongqun Guo, Lijuan Liu, Yang Geng, Hongling Wu, Juan Du, Zheng Hu, Sheng Xu, Jiekai Chen, Aibin He, Bing Liu, Demin Wang, Yong-Guang Yang, Jinyong Wang*. Transcription factor Hoxb5 reprograms B cells into functional T lymphocytes. Nature Immunology. 2018, 19(3): 279-290.
2. Xuejia Li, Chengxiang Xia, Tongjie Wang, Lijuan Liu, Qianhao Zhao, Dan Yang, Fangxiao Hu, Mengyun Zhang, Ke Huang, Yang Geng, Yi Zheng, Yuxian Guan, Hongling Wu, Xiaoli Chen, Guangjin Pan, Jiekai Chen, Juan Du*, Jinyong Wang*. Pyrimidoindole derivative UM171 enhances derivation of hematopoietic progenitor cells from human pluripotent stem cells. Stem Cell Research. 2017, 21: 32-39.
3. Xiaoli Chen#, Qianhao Zhao#, Chen Li#, Yang Geng, Ke Huang, Jian Zhang, Xiaoshan Wang, Jiaqi Yang, Tongjie Wang, Chengxiang Xia, Xiaofei Liu, Minghui Meng, Dan Yang, Yi Zheng, Juan Du, Xiangzhong Zhang, JiekaiChen, Guangjin Pan, Jinyong Wang*. OP9-Lhx2 stromal cells facilitate derivation of hematopoietic progenitors both in vitro and in vivo. Stem Cell Research. 2015, 15(2): 395-402.
4. Dan Yang#, Xiangzhong Zhang#, Yong Dong#, Tongjie Wang, Xiaoshan Wang, Yang Geng, Shumin Fang, Yi Zheng, Xiaoli Chen, Jiekai Chen, Guangjin Pan, Jinyong Wang*. Enforced Expression of Hoxa5 in heamatopoietic stem cells leads to aberrant erythropoiesis in vivo. Cell Cycle. 2015, 14(4): 612-620.
5. Jinyong Wang#, Guangyao Kong#, Yangang Liu, Juan Du, Yuan-I Chang, Sin ruow They, Xinmin Zhang, Erik A. Ranheim, Marc K. Saba-El-Leil, Sylvain Meloche, Alisa Damnernsawad, Jingfang Zhang, Jing zhang*. NrasG12D/+ promotes leukemogenesis by aberrantly regulating hematopoietic stem cell functions. Blood, 2013, 121(26): 5203-5207."
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